Analytical Data
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基因名
CSN3
- Application
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别名
CSN3；CSN3；COP9 signalosome complex subunit 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07498
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表达区间
21-182aa
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氨基酸序列
EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP TA
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSN3, also known as the gamma subunit of the COP9 signalosome, plays a crucial role in various cellular processes, including signal transduction, transcription regulation, and the modulation of protein stability. The COP9 signalosome is a complex that consists of eight subunits and is involved in the removal of ubiquitin from proteins, thus influencing their degradation and activity. Research has increasingly focused on CSN3 due to its potential implications in pathophysiological conditions, including cancer, neurodegenerative diseases, and immune responses. The interest in recombinant CSN3 expresses a desire to understand its molecular mechanisms, as well as to explore its function in cellular pathways and interactions with other proteins. Advances in recombinant DNA technology have enabled scientists to produce CSN3 in various expression systems, allowing for detailed structural and functional studies. By elucidating the role of CSN3, researchers hope to identify novel therapeutic targets and strategies for diseases linked to dysregulated protein degradation. Additionally, exploring the biophysical properties of recombinant CSN3 can aid in the design of inhibitors or modulators that may serve as potential drug candidates. Overall, the study of CSN3 recombinant protein is pivotal for advancing our knowledge of cellular signaling mechanisms and developing innovative treatments for diseases associated with the COP9 signalosome dysregulation.
