Analytical Data
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基因名
GPR135
- Application
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别名
GPR135; G-protein coupled receptor 135
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZ08
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表达区间
1-494aa
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氨基酸序列
MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASGGGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSL
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分子量
51.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR135, a member of the G protein-coupled receptor (GPCR) family, has emerged as an intriguing target for research due to its incomplete characterization and potential roles in various physiological processes. GPCRs are crucial mediators of cellular signaling and are involved in numerous biological functions, including neurotransmission, immune responses, and endocrine signaling. Studies suggest that GPR135 may participate in metabolic regulation and has been implicated in several pathophysiological conditions, including obesity and diabetes. However, its specific ligands and signaling pathways remain poorly understood, making it a compelling subject for investigation. Research on recombinant GPR135 protein aims to elucidate its structure-function relationships, identify endogenous and synthetic ligands, and explore its interactions with G proteins and other signaling partners. Through expression in heterologous systems, scientists can obtain large quantities of the protein necessary for biochemical and biophysical analyses. Understanding GPR135's mechanism of action could reveal novel therapeutic strategies for diseases related to metabolic dysregulation, positioning GPR135 as a potentially significant player in drug discovery and biomedical research. As our understanding of this receptor deepens, it may open new avenues for targeted therapies and enhance our grasp of GPCR biology.
