Analytical Data
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基因名
GPR50
- Application
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别名
GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13585
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表达区间
1-617aa
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氨基酸序列
MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVVDVEDDPDEMAV
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分子量
93.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR50, a member of the G protein-coupled receptor family, has garnered significant attention due to its potential role in various physiological processes and its implications in metabolic and neuropsychiatric disorders. Emerging studies have suggested that GPR50 may influence circadian rhythms, energy metabolism, and mood regulation, linking it to conditions such as obesity, depression, and sleep disorders. The receptor exhibits unique characteristics, including its ability to form heterodimers with other receptors, which could modulate their functions and signaling pathways. Given its involvement in critical biological processes, research into GPR50 has focused on the characterization and functional analysis of its recombinant protein. This involves expressing GPR50 in heterologous systems to study its pharmacological properties, ligand binding, and downstream signaling mechanisms. Understanding GPR50's structure-function relationship and its interactions with ligands and other proteins is vital for elucidating its role in health and disease. Additionally, the development of specific GPR50 antagonists or agonists could provide novel therapeutic avenues for treating related disorders. Overall, the study of GPR50 recombinant protein is pivotal in advancing our knowledge of this enigmatic receptor and its potential as a target for drug discovery.
