Analytical Data
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Gene name
GPR63
- Application
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Alternative Names
GPR63; PSP24B; Probable G-protein coupled receptor 63; PSP24-2; PSP24-beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZJ6
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Expression Region
1-419aa
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AA Sequence
MVFSAVLTAFHTGTSNTTFVVYENTYMNITLPPPFQHPDLSPLLRYSFETMAPTGLSSLTVNSTAVPTTPAAFKSLNLPLQITLSAIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTTRWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPFLVILYSFMGILNTLRHNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTTILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMMPKSFKFLPQLPGHTKRRIRPSAVYVCGEHRTVV
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Molecular Weight
47.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR63, also known as the G protein-coupled receptor 63, is a member of the family of G protein-coupled receptors (GPCRs) that play critical roles in various physiological processes. This receptor has garnered interest due to its potential involvement in the modulation of neuronal signaling and its implications in neurological disorders. Recent studies have suggested that GPR63 might influence behavioral outcomes and could be linked to conditions such as depression and anxiety. The research surrounding GPR63 recombination protein has become increasingly important, as it offers insights into the receptor's functional mechanisms and its role in signal transduction pathways. Through the production of recombinant GPR63, scientists aim to investigate the receptor's structure-function relationships, ligand-binding affinities, and downstream signaling effects. Understanding GPR63 at a biochemical and cellular level could pave the way for therapeutic interventions targeting GPCRs in various diseases. Additionally, characterizing the recombinant protein can aid in elucidating its interactions with other cellular proteins and contribute to the broader knowledge of GPCR biology. As the research on GPR63 continues to evolve, its significance in pharmacology and therapeutic development becomes more pronounced, highlighting the need for further investigation into this intriguing receptor.
