Analytical Data
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Gene name
GSDML
- Application
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Alternative Names
123; 156; Gasdermin B; Gasdermin like protein; Gasdermin-B; Gasdermin-like protein; GSDMB; GSDMB_HUMAN; GSDML; PP4052; PRO2521
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TAX9
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Expression Region
1-411aa
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AA Sequence
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISRELHMEDSDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELAEGPTSVSS
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Molecular Weight
70.95 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GSDML, or Gasdermin-L, is a member of the gasdermin family of proteins, known for their role in regulating cell death and inflammation. The understanding of GSDML has been fueled by the growing interest in its involvement in pyroptosis, a form of programmed cell death associated with inflammatory responses. Recent studies have identified GSDML as a critical mediator in this process, which is triggered by various pathogenic infections and cellular stressors. Researchers have noted that GSDML can form pores in cellular membranes, leading to the release of pro-inflammatory cytokines and promoting the immune response. The investigation of GSDML's structure and function is crucial not only for comprehending its role in immunity but also for exploring therapeutic interventions for diseases characterized by dysregulated inflammation, such as autoinflammatory disorders and certain cancers. As studies continue to unravel the complex mechanisms of GSDML and its interactions with other cellular components, there is potential for developing novel strategies that target this pathway, aiming to modulate immune responses and offer new hope in treating inflammatory and malignancies. This ongoing research underscores the significance of GSDML in both basic biology and potential clinical applications, marking it as a prominent focus in the field of cellular and molecular biology.
