Analytical Data
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Gene name
ADAM33
- Application
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Alternative Names
ADAM33；ALS2CR4；Transmembrane Protein 237
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZ11
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Expression Region
30-701aa
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AA Sequence
VLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDT
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Molecular Weight
78.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADAM33, a member of the ADAM (A Disintegrin and Metalloproteinase) family, has garnered significant attention due to its association with asthma and other allergic diseases. Identified as a candidate gene linked to airway hyperresponsiveness and inflammation, ADAM33 is implicated in the processes of tissue remodeling and inflammation in the respiratory system. Research indicates that ADAM33 is highly expressed in bronchial tissue and is involved in the shedding of various cell surface proteins, including cytokines and adhesion molecules, which play crucial roles in immune response and cell signaling. The protein's extracellular metalloproteinase domain suggests a functional role in proteolytic activity, potentially affecting lung function and inflammatory pathways. Genetic polymorphisms in the ADAM33 gene have been associated with an increased risk of developing asthma, highlighting its relevance in genetic predisposition to respiratory diseases. Given these insights, the recombinant expression and functional characterization of ADAM33 protein could provide vital information in understanding its role in asthma pathophysiology. This research may pave the way for novel therapeutic approaches targeting ADAM33, ultimately improving management strategies for individuals with asthma and related respiratory disorders. Through recombinant protein technology, scientists aim to elucidate the mechanistic actions of ADAM33, contributing to the broader understanding of its significance in airway diseases and enhancing biomarker development for disease prediction and progression monitoring.
