Analytical Data
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基因名
MYL1
- Application
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别名
MYL1；Myosin light chain 1/3. skeletal muscle isoform
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05976
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表达区间
3-142aa
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氨基酸序列
PKKDVKKP VAAAAAAPAP APAPAPAPAP AKPKEEKIDL SAIKIEFSKE QQDEFKEAFL LFDRTGDSKI TLSQVGDVLR ALGTNPTNAE VRKVLGNPSN EELNAKKIEF EQFLPMMQAI SNNKDQATYE DFVEGLRVFD KE
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MYL1, or Myosin Light Chain 1, is a crucial component of the myosin protein family, playing a key role in muscle contraction and cellular motility. It is predominantly expressed in cardiac and skeletal muscle tissues, where it regulates actin filaments by modulating the activity of myosin II, thus influencing contractile function. Recent studies have highlighted the significance of MYL1 in various pathophysiological conditions, including cardiac hypertrophy, heart failure, and other muscle-related diseases. The ability to produce recombinant MYL1 protein has opened new avenues for functional studies, enabling researchers to investigate its structure-function relationships, interaction with other proteins, and post-translational modifications. Understanding the precise mechanisms by which MYL1 regulates muscle contraction is essential for developing therapeutic strategies for related disorders. Additionally, recombinant MYL1 has potential applications in drug testing and the development of muscle regenerative therapies. Given the complex regulatory roles of MYL1 in cardiac and skeletal muscle physiology, further research into its recombinant production and subsequent functional analysis is vital for advancing our knowledge of muscle biology and enhancing clinical outcomes for patients with muscular and cardiac diseases.
