Analytical Data
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基因名
GRA2
- Application
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别名
GRA2；Glycine receptor subunit alpha-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23416
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表达区间
1-452aa
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氨基酸序列
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRA2, a protein derived from Toxoplasma gondii, has become a focal point of research due to its critical role in the life cycle of this intracellular parasite that affects a significant portion of the global population. As a member of the dense granule proteins, GRA2 is involved in modulating host immune responses and facilitating parasitic survival within host cells. Its structural characteristics and functionalities suggest potential interactions with various host cellular pathways, making it a candidate for understanding T. gondii pathogenesis and establishing a chronic infection. Studies have shown that GRA2 is secreted into the host cell cytoplasm, where it can influence the host's immune response, potentially aiding in immune evasion. The protein has garnered interest for its potential as a diagnostic marker or vaccine candidate, particularly in immunocompromised individuals at risk of severe disease. Additionally, the exploration of GRA2’s role in the development of T. gondii's persistent infection sheds light on the intricate host-parasite interactions, which could lead to novel therapeutic strategies. The challenges in controlling Toxoplasma infections underline the importance of GRA2 research in contributing to broader insights into parasitology and immune modulation, positioning it as an essential component in the fight against this ubiquitous parasite. By elucidating the mechanisms of GRA2 interaction with the host, researchers aim to pave the way for innovative interventions to combat Toxoplasma gondii-related diseases.
