Analytical Data
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Gene name
GRA2
- Application
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Alternative Names
GRA2；Glycine receptor subunit alpha-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23416
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Expression Region
1-452aa
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AA Sequence
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
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Molecular Weight
52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRA2, a protein derived from Toxoplasma gondii, has become a focal point of research due to its critical role in the life cycle of this intracellular parasite that affects a significant portion of the global population. As a member of the dense granule proteins, GRA2 is involved in modulating host immune responses and facilitating parasitic survival within host cells. Its structural characteristics and functionalities suggest potential interactions with various host cellular pathways, making it a candidate for understanding T. gondii pathogenesis and establishing a chronic infection. Studies have shown that GRA2 is secreted into the host cell cytoplasm, where it can influence the host's immune response, potentially aiding in immune evasion. The protein has garnered interest for its potential as a diagnostic marker or vaccine candidate, particularly in immunocompromised individuals at risk of severe disease. Additionally, the exploration of GRA2’s role in the development of T. gondii's persistent infection sheds light on the intricate host-parasite interactions, which could lead to novel therapeutic strategies. The challenges in controlling Toxoplasma infections underline the importance of GRA2 research in contributing to broader insights into parasitology and immune modulation, positioning it as an essential component in the fight against this ubiquitous parasite. By elucidating the mechanisms of GRA2 interaction with the host, researchers aim to pave the way for innovative interventions to combat Toxoplasma gondii-related diseases.
