Analytical Data
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基因名
CK16
- Application
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别名
CK16；C11orf56；FAM160A2；KIAA1759；FHF complex subunit HOOK-interacting Protein 1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08779
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表达区间
1-473aa
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氨基酸序列
MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSRFSSGG ACGLGGGYGG GFSSSSSFGS GFGGGYGGGL GAGFGGGLGA GFGGGFAGGD GLLVGSEKVT MQNLNDRLAS YLDKVRALEE ANADLEVKIR DWYQRQRPSE IKDYSPYFKT IEDLRNKIIA ATIENAQPIL QIDNARLAAD DFRTKYEHEL ALRQTVEADV NGLRRVLDEL TLARTDLEMQ IEGLKEELAY LRKNHEEEML ALRGQTGGDV NVEMDAAPGV DLSRILNEMR DQYEQMAEKN RRDAETWFLS KTEELNKEVA SNSELVQSSR SEVTELRRVL QGLEIELQSQ LSMKASLENS LEETKGRYCM QLSQIQGLIG SVEEQLAQLR CEMEQQSQEY QILLDVKTRL EQEIATYRRL LEGEDAHLSS QQASGQSYSS REVFTSSSSS SSRQTRPILK EQSSSSFSQG QSS
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分子量
51.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK16 recombinant protein, derived from the cytokeratin 16 gene, plays a significant role in various biological processes, particularly in maintaining the structural integrity of epithelial tissues. Its expression is predominantly observed in stratified squamous epithelia, such as in the skin and mucosal surfaces, where it contributes to the formation and function of the keratinocyte layer. Pathologically, CK16 is upregulated in response to skin injuries, inflammatory conditions, and certain diseases, such as psoriasis and other hyperproliferative disorders. Researchers have identified CK16 as a potential biomarker for these conditions, enhancing its relevance in clinical diagnostics and therapeutic strategies. The production of CK16 recombinant protein allows for detailed studies of its structural and functional properties, facilitating insights into its role in keratinocyte biology and tissue repair mechanisms. Furthermore, the recombinant form can be utilized in various applications, including the development of skin substitutes and regenerative medicine. Understanding CK16's functional implications can provide avenues for novel treatments targeting epithelial disorders, making it a focus of ongoing biomedical research.
