Analytical Data
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基因名
DNAJA1
- Application
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别名
DNAJA1；DNAJ2；HDJ2；HSJ2；DnaJ homolog subfamily A member 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31689
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表达区间
1-394aa
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氨基酸序列
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC
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分子量
52.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJA1, a member of the DnaJ/Hsp40 family of heat shock proteins, plays a crucial role in cellular protein folding and stress response. It functions as a co-chaperone, assisting in the proper folding of proteins and preventing the aggregation of misfolded proteins, which can lead to cellular dysfunction and contribute to various diseases, including neurodegenerative disorders. Due to its essential role in maintaining proteostasis, DNAJA1 has garnered significant attention in the fields of molecular biology and biochemistry. Research has shown that its expression can be upregulated under stress conditions, highlighting its potential as a therapeutic target or biomarker for diseases related to protein misfolding. Furthermore, studies have revealed that DNAJA1 interacts with numerous client proteins, influencing their stability and functionality. This has led to increased interest in the development of DNAJA1 recombinant proteins for functional assays, structural studies, and potential therapeutic applications. Understanding the intricate mechanisms of DNAJA1 and its interactions could provide insights into the molecular basis of various pathologies and pave the way for novel interventions in related diseases. Thus, the investigation of DNAJA1 recombinant proteins is a promising area of research with implications for improving our understanding of cellular stress responses and the development of strategies to combat diseases associated with protein misfolding.
