Analytical Data
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Gene name
Pcp4
- Application
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Alternative Names
Pcp4；PEP19；Calmodulin regulator Protein PCP4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48539
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Expression Region
1-62aa
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AA Sequence
MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS QS
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Molecular Weight
6.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of Pcp4 (Purkinje Cell Protein 4) recombinant proteins has garnered significant interest due to their crucial role in cerebellar function and development. Pcp4 is a highly conserved protein primarily expressed in Purkinje cells, where it is involved in synaptic transmission and neuronal signaling. Its dysregulation has been linked to various neurological disorders, including ataxias and other cerebellar dysfunctions, making it a potential biomarker for these conditions. Researchers seek to understand the molecular mechanisms underlying Pcp4's function, including its interactions with ion channels and other proteins that regulate neuronal excitability. By producing recombinant Pcp4 proteins, scientists can investigate their biophysical properties, structure-function relationships, and impact on neuronal behavior in vitro. This approach not only aids in elucidating the physiological relevance of Pcp4 in cerebellar circuitry but also opens up avenues for potential therapeutic interventions in neurodegenerative diseases. Furthermore, understanding Pcp4's role at the molecular level may reveal novel pathways that contribute to neuronal resilience and plasticity, highlighting its importance in neuroscience research.
