Analytical Data
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Gene name
GSTT2
- Application
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Alternative Names
GSTT2B;GSTT2;Glutathione S-transferase theta-2B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0CG30
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Expression Region
1-244aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSTT2 (Glutathione S-transferase theta 2) is a member of the glutathione S-transferase (GST) superfamily, which plays a crucial role in the detoxification of harmful compounds through conjugation with glutathione. It is primarily involved in the metabolism of xenobiotics and endogenous compounds, thereby contributing to cellular defense mechanisms against oxidative stress and chemical insults. Recent research has highlighted the significance of GSTT2 in various pathological conditions, including cancer, where its expression levels may correlate with tumor progression and drug resistance. Furthermore, GSTT2 has been implicated in the metabolism of specific chemotherapeutic agents, suggesting that it may influence the efficacy of cancer treatments. The recombinant expression of GSTT2 in laboratory settings provides a valuable tool for studying its enzymatic properties, substrate specificity, and potential as a therapeutic target. Understanding GSTT2's structure and function can aid in developing novel strategies for enhancing drug efficacy and mitigating resistance in cancer therapies. Recent advances in biotechnology and structural biology have enabled researchers to produce and characterize recombinant GSTT2, allowing for detailed investigations into its biochemical properties and interactions with potential inhibitors. As research unfolds, GSTT2 continues to emerge as a significant biomolecule with promising applications in personalized medicine and drug design, emphasizing the need for further studies to elucidate its role in human health and disease.
