Analytical Data
-
Gene name
HPN
- Application
-
Alternative Names
HPN; TMPRSS1; Serine protease hepsin; Transmembrane protease serine 1
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P05981
-
Expression Region
40-417aa
-
AA Sequence
VAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFACEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
-
Molecular Weight
67.43 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HPN (hepatocyte growth factor activator) is a serine protease that plays a crucial role in the activation of hepatocyte growth factor (HGF), which is involved in various physiological processes such as tissue regeneration, cell migration, and angiogenesis. The research into HPN has gained momentum due to its significant implications in cancer biology, particularly in the tumor microenvironment where it can influence tumor growth and metastasis. Previous studies have highlighted a correlation between HPN expression levels and poor prognosis in certain cancers, suggesting that HPN could serve as a potential biomarker for cancer progression. Furthermore, the therapeutic modulation of HPN activity may offer novel strategies for cancer treatment, making it a target of interest for drug development. Understanding the molecular mechanisms underlying HPN's role in cell signaling pathways is essential for elucidating its functions and therapeutic potential. As such, ongoing research aims to unravel the complexities of HPN activity, investigate its interactions with other proteins, and explore its potential applications in regenerative medicine and oncology. The exploration of recombinant HPN proteins has also opened new avenues for pharmaceutical applications, enhancing our understanding of its structure-function relationships and paving the way for innovative treatments targeting HPN-related diseases.











