Analytical Data
-
Gene name
TNFR1
- Application
-
Alternative Names
TNFR1；Tumor necrosis factor receptor type 1-associated DEATH domain Protein
-
Species
Human
-
Source
E. coli
-
Tag
N-6His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P19438
-
Expression Region
60-236aa
-
Molecular Weight
22 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Tumor necrosis factor receptor 1 (TNFR1) is a critical receptor in the inflammatory and immune response, primarily mediating the effects of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine. Research on TNFR1 is essential due to its role in various pathological conditions, including autoimmune diseases, cancer, and neurodegenerative disorders. TNFR1 signaling pathways are complex, leading to both cell survival and apoptosis, which are pivotal in maintaining immune homeostasis. Understanding these pathways can reveal potential therapeutic targets for modulating immune responses. The development of recombinant TNFR1 proteins has advanced our ability to study this receptor's function in vitro and in vivo. By producing TNFR1 as a recombinant protein, researchers can investigate its interactions with ligands and downstream signaling molecules, elucidate its structural properties, and assess its potential as a therapeutic agent. Moreover, recombinant TNFR1 proteins facilitate the development of antagonists or agonists that can selectively modulate TNF-α signaling, offering insights into new treatment strategies for diseases driven by TNF-α dysregulation. As a result, ongoing studies of TNFR1 not only enhance our understanding of its biological roles but also pave the way for innovative approaches in therapeutics targeting inflammation and immune-related disorders.
