Analytical Data
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Gene name
ARRb2
- Application
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Alternative Names
ARRb2；ARB2；ARR2；Beta-arrestin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32121
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Expression Region
1-409aa
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AA Sequence
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLK DRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTR LQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAF CAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHL EASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQY KCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTN LASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH DHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMK DDDYDDQLC
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Molecular Weight
73 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARRb2 (arrhythmogenic right ventricular cardiomyopathy protein 2) is a critical protein implicated in the regulation of cardiac function and the pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC), a genetic heart disease characterized by ventricular arrhythmias and risk of sudden cardiac death. Research into ARRb2 has gained traction as understanding its role can elucidate the molecular mechanisms underpinning ARVC and potentially lead to targeted therapies. The protein is known to be involved in various cellular processes, including cardiac cell signaling, contractility, and apoptosis. Mutations in the ARRb2 gene have been associated with familial cases of ARVC, highlighting its significance in inherited cardiovascular conditions. Recent studies focus on the expression, structure, and function of recombinant ARRb2 proteins to better understand how specific mutations alter its properties and contribute to disease pathology. Employing advanced techniques such as molecular cloning, protein purification, and functional assays, researchers aim to dissect the contributions of ARRb2 to cardiac health and disease. Such insights not only advance our comprehension of ARVC but also pave the way for novel therapeutic strategies, enhancing patient outcomes in those affected by this debilitating condition.
