Analytical Data
-
基因名
Il33
- Application
-
别名
C9orf26; CHROMOSOME 9 OPEN READING FRAME 26; DKFZp586H0523; DVS27; DVS27 related protein; IL 1F11; IL 33; IL-1F11; IL-33; IL1F11 ; IL33; IL33_HUMAN; Interleukin 1 family member 11; Interleukin 33; INTERLEUKIN 33 NFHEV; Interleukin 33 precursor ; Interleukin-1 family member 11; Interleukin-33 (109-270); Interleukin33; NF HEV; NF-HEV; NFEHEV
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O95760
-
表达区间
1-270aa
-
氨基酸序列
MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET
-
分子量
57.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human HS3ST1 Protein，His
Cat：PA1000-1499
Recombinant E.coli cdtA Protein，His
Cat：PA2000-4319
Recombinant Human IL28RA Protein，GST
Cat：PA2000-8460
Protein Description
IL-33, an interleukin of the IL-1 family, plays a critical role in immune regulation and inflammation. It is primarily produced by epithelial cells and functions as an alarmin, alerting the immune system to injury or infection. Elevated levels of IL-33 have been associated with various inflammatory and autoimmune diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. Its mechanism involves activation of ST2 (suppressor of tumorigenicity 2), a receptor that modulates Th2 cell responses and promotes the production of pro-inflammatory cytokines. Research into recombinant IL-33 protein has gained traction due to its potential therapeutic applications; it may serve as a biomarker for disease severity or as a target for novel treatments aimed at modulating immune responses. The development of recombinant IL-33 enables detailed studies on its structure, function, and interactions within the immune system, further elucidating its role in health and disease. Understanding the biochemical pathways activated by IL-33 may pave the way for new interventions in conditions characterized by Type 2 inflammation. As such, the investigation of recombinant IL-33 is not only vital for advancing fundamental immunological knowledge but also holds promise for innovative therapeutic strategies.
