Analytical Data
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基因名
ING4
- Application
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别名
Brain my036 protein; Candidate tumor suppressor p33 ING 1 homolog; Candidate tumor suppressor p33 ING1 homolog; D6Wsu147e; D6Xrf92; ING 1 like protein; ING 4; ING1 like protein; ING4; ING4_HUMAN; Inhibitor of growth family member 4; Inhibitor of growth family member 4 long isoform; Inhibitor of growth protein 4; MGC12557; my036; p29 ING 4; p29 ING4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNL4
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表达区间
1-249aa
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氨基酸序列
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP RCSQERKKK
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分子量
28.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ING4 protein, a member of the inhibitor of growth (ING) family, has garnered significant interest in the field of cancer research due to its role as a potential tumor suppressor. Research has indicated that ING4 is involved in various cellular processes, including regulation of gene expression, cell cycle control, and DNA damage response. Mutations and decreased expression of ING4 have been associated with the progression of several cancers, suggesting that it may play a crucial role in maintaining cellular homeostasis and preventing malignancy. Additionally, ING4 has been implicated in the modulation of the p53 pathway, further linking it to critical tumor-suppressive functions. Investigations into the structural characteristics of ING4 have provided insights into its interaction with other proteins and its functional mechanisms within the cell. As such, understanding ING4's role in tumor biology not only enhances our comprehension of cancer mechanisms but also opens avenues for novel therapeutic strategies aimed at reinstating its function in cancerous cells. The study of ING4, therefore, presents both a compelling narrative of tumor suppression and a potential target for innovative cancer treatments.
