Analytical Data
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Gene name
KIN
- Application
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Alternative Names
KIN; BTCD; KIN17DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN; antigenic determinant of recA protein homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60870
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Expression Region
1-393aa
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AA Sequence
MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH QRQLLLASEN PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS HREHIHMNAT QWETLTDFTK WLGREGLCKV DETPKGWYIQ YIDRDPETIR RQLELEKKKK QDLDDEEKTA KFIEEQVRRG LEGKEQEVPT FTELSRENDE EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK RKESSQSSTQ SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY RGNEGTLESI NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA
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Molecular Weight
45.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIN proteins, or kinase-interacting proteins, are pivotal in the regulation of various cellular processes, including signal transduction and cellular proliferation. The kinase family of enzymes plays a crucial role in transferring phosphate groups from ATP to specific substrates, leading to the modulation of protein function and activity. Research into KIN proteins has gained momentum due to their implications in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. These proteins often act as scaffolds, facilitating interactions between different signaling molecules, which underscores their importance in maintaining cellular homeostasis. Additionally, dysregulation of KIN protein interactions can lead to aberrant signaling pathways, contributing to disease pathology. Recent advancements in molecular biology techniques, such as CRISPR gene editing and high-throughput screening, have enabled scientists to explore the complex networks involving KIN proteins more effectively. Understanding the specific roles and mechanisms of KIN protein interactions could pave the way for novel therapeutic strategies, as targeting these proteins may provide new avenues for intervention in diseases characterized by dysfunctional signaling pathways. Thus, the study of KIN proteins not only enhances our comprehension of fundamental biological processes but also holds the potential for significant clinical applications in mitigating the effects of various health conditions.
