Analytical Data
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Gene name
CACNa1S
- Application
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Alternative Names
CACNa1S；SH3 and cysteine-rich domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13698
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
212 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The CACNA1S gene encodes the alpha-1 subunit of the L-type voltage-gated calcium channels, which play a crucial role in the excitation-contraction coupling in skeletal muscle cells. Mutations in CACNA1S can lead to various pathological conditions, including hypokalemic periodic paralysis and malignant hyperthermia, making it a significant target for research in neuromuscular diseases and pharmacological studies. Understanding the structure and function of the CACNA1S protein is essential for elucidating the molecular mechanisms underlying these disorders and developing potential therapeutic strategies. The recombinant expression of CACNA1S protein allows for detailed biochemical and biophysical characterization, facilitating the study of its ion channel properties, interaction with regulatory proteins, and response to pharmacological agents. Such studies are vital for advancing our knowledge of calcium channel physiology and pathophysiology, ultimately contributing to improved diagnosis and treatment of associated diseases. Additionally, recombinant CACNA1S proteins serve as valuable tools in drug discovery, particularly in screening compounds that can modulate channel activity for therapeutic benefit.
