Analytical Data
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Gene name
MSTN
- Application
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Alternative Names
MSTN;GDF8;Growth/differentiation factor 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14793
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Expression Region
24-375aa
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AA Sequence
HHHHHHASNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLR LETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATT ETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVET PTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNW LKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSR RDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEF VFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIP AMVVDRCGCS
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Molecular Weight
71 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MSTN, or myostatin, is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a significant role in regulating skeletal muscle growth and development. It is primarily known for its function as a negative regulator of muscle mass, meaning that it inhibits muscle differentiation and proliferation. Elevated levels of myostatin are associated with muscle wasting conditions, such as cachexia, muscular dystrophy, and age-related sarcopenia, raising interest in its potential as a therapeutic target. The use of recombinant MSTN proteins in research allows scientists to better understand its molecular mechanisms and interactions in muscle biology. By studying the effects of MSTN on muscle cells, researchers aim to identify strategies for counteracting muscle loss and promoting muscle regeneration. In this context, recombinant myostatin proteins are also investigated for their potential in developing treatments for muscle-related disorders and enhancing muscle growth in livestock for agricultural purposes. As a result, the development and characterization of MSTN recombinant proteins play a pivotal role in advancing our understanding of muscle regulation and the potential for innovative therapeutic interventions.
