Analytical Data
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基因名
LILRB5
- Application
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别名
LILRB5; LIR8; Leukocyte immunoglobulin-like receptor subfamily B member 5; CD85 antigen-like family member C; Leukocyte immunoglobulin-like receptor 8; LIR-8; CD antigen CD85c
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75023
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表达区间
1-590aa
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氨基酸序列
MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIARGKPVTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPGPEDQPLTPTGLDPQSGLGRHLGVVTGVSVAFVLLLFLLLFLLLRHRHQSKHRTSAHFYRPAGAAGPEPKDQGLQKRASPVADIQEEILNAAVKDTQPKDGVEMDARAAASEAPQDVTYAQLHSLTLRREATEPPPSQEREPPAEPSIYAPLAIH
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分子量
90.64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LILRB5 (Leukocyte Immunoglobulin-Like Receptor B5) is a member of the LILR family, which plays a crucial role in the immune system by modulating immune responses. It is primarily expressed on the surface of immune cells, including myeloid cells and lymphocytes, and is involved in regulating the activity of immune checkpoints. The study of LILRB5 has gained attention due to its potential implications in various diseases, including cancers, autoimmune disorders, and infectious diseases. Research has shown that LILRB5 can interact with MHC class I molecules, influencing T cell activation and tolerance. The engineering of LILRB5 recombinant proteins provides a valuable tool for elucidating its structural and functional properties, as well as its role in immune regulation. These recombinant proteins can be utilized to produce antibodies, develop therapeutic agents, or enhance our understanding of immune mechanisms. Consequently, ongoing research into LILRB5 is essential for uncovering its role in pathology and for developing novel immunotherapeutic strategies that may harness or inhibit its activity to improve disease outcomes. Through these efforts, scientists hope to identify new pathways for intervention and therapeutic targets that could lead to advancements in immunotherapy and personalized medicine. Thus, LILRB5 stands at the intersection of immunology and therapeutic development, warranting focused investigation in the context of modern biomedical research.
