Analytical Data
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Gene name
PHF6
- Application
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Alternative Names
PHF6；CENP-31；KIAA1823；PHD finger Protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IWS0
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Expression Region
2-312aa
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AA Sequence
SSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMAYCRKHKKTAHNSEAADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMVCSFYICYATLHLICCFKFRVHPKFIQSSENLK
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Molecular Weight
39.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHF6 (PHD finger protein 6) is a member of the PHD finger domain-containing proteins, which play crucial roles in various cellular processes, including gene regulation and chromatin remodeling. Mutations in the PHF6 gene are associated with Börjeson-Forssman-Lehmann syndrome, a rare genetic disorder characterized by developmental delays, intellectual disability, and various physical anomalies. The study of PHF6 recombinant protein has gained attention due to its potential implications in understanding the molecular mechanisms underlying these developmental disorders. Researchers aim to elucidate the structure-function relationship of PHF6, which may provide insights into its role in epigenetic regulation and transcriptional modulation. By producing recombinant PHF6 protein, scientists can investigate its interactions with other cellular partners, explore its binding affinity to histones, and assess its impact on chromatin dynamics. This research not only helps in delineating the biological functions of PHF6 but also has the potential to inform therapeutic strategies for conditions associated with its dysfunction. As the understanding of PHF6's role in cellular biology expands, it could pave the way for further exploration of its therapeutic potential in epigenetic-related diseases.
