Analytical Data
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基因名
LRRC5
- Application
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别名
LRRC8D; LRRC5; UNQ213/PRO239; Volume-regulated anion channel subunit LRRC8D; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L1W4
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表达区间
1-143aa
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氨基酸序列
MVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTASPFPNQ
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分子量
41.47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRC5 (Leucine-Rich Repeat Containing 5) is a protein that plays a critical role in the immune response and has garnered attention in research due to its involvement in various biological processes, including antigen presentation and viral infection. It is primarily expressed in hematopoietic tissues and has been linked to the regulation of immune cell functions, particularly in the context of T-cell activation and differentiation. Post-translational modifications, such as phosphorylation, may also influence its function, making it a target of interest for therapeutic interventions. Recent studies suggest that LRRC5 might participate in the modulation of dendritic cell activity and may affect the host's susceptibility to infections, particularly viral ones. Given the rise of infectious diseases and the need for effective vaccines and treatments, understanding the structure and function of LRRC5 is critical. The development of recombinant LRRC5 proteins allows researchers to investigate its specific interactions and functional roles, paving the way for potential applications in immunotherapy and vaccine design. By elucidating the mechanisms through which LRRC5 operates, scientists aim to harness its capabilities to enhance immune responses against pathogens, thus contributing to the development of new strategies for disease prevention and treatment.
