Analytical Data
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基因名
PPP2R2B
- Application
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别名
PPP2R2B；Immediate early response gene 5 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q00005
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表达区间
1-443aa
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氨基酸序列
MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
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分子量
56.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP2R2B, also known as protein phosphatase 2 regulatory subunit B beta, is a crucial component of the protein phosphatase 2A (PP2A) complex, which plays a vital role in various cellular processes, including cell growth, differentiation, and apoptosis. Abnormalities in PP2A activity have been linked to several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. The regulatory subunits, like PPP2R2B, are essential for the proper assembly and function of the PP2A holoenzyme, influencing its substrate specificity and regulatory mechanisms. Research on the recombinant expression and characterization of PPP2R2B is significant for understanding its role in cellular signaling pathways and the wider implications of PP2A regulation in pathophysiological conditions. Recombinant PPP2R2B can be utilized to study its interactions with various proteins and to elucidate its potential as a therapeutic target. Moreover, the ability to produce this protein in a recombinant form opens avenues for drug discovery and the development of novel therapeutic strategies aimed at modulating PP2A activity in diseases characterized by altered phosphatase signaling. Understanding the structural and functional properties of PPP2R2B is crucial for developing targeted interventions and elucidating the complexities of PP2A's involvement in health and disease. Overall, the study of PPP2R2B and its recombinant form is integral to advancing our knowledge of cellular regulation and the potential for therapeutic advancements in human health.
