Analytical Data
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基因名
a4GALT
- Application
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别名
a4GALT；A14GALT；A4GALT1；Lactosylceramide 4-alpha-galactosyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPC4
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表达区间
1-353aa
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氨基酸序列
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKG QLYNLPAEIPCPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVES AARTHPESHVLVLMKGLPGGNASLPRHLGISLLSCFPNVQMLPLDLRELF RDTPLADWYAAVQGRWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKN LRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDHYNGWIWGHQG PQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDIN PEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMK MYL
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分子量
67 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the A4GALT recombinant protein is centered on its role in glycosylation processes, particularly the transfer of galactose to the core structure of glycoproteins and glycolipids. A4GALT, or alpha-1,4-galactosyltransferase, is crucial in the synthesis of glycan structures that contribute to cellular communication, recognition, and immune response. Alterations or deficiencies in A4GALT can lead to various pathological conditions, including immune deficiencies and certain types of cancer, highlighting the importance of this enzyme in maintaining cellular homeostasis. Research into A4GALT recombinant protein aims to elucidate its biochemical properties, substrate specificity, and regulation mechanisms, which can further our understanding of glycosylation pathways. This knowledge not only contributes to basic biological science but also holds potential for therapeutic applications, such as the development of targeted treatments for conditions arising from glycosylation defects. Additionally, the production of A4GALT as a recombinant protein facilitates the exploration of its function in vivo, enabling scientists to study its interactions within complex biological systems. Overall, investigating A4GALT offers critical insights into the broader implications of glycosylation in health and disease, paving the way for novel intervention strategies.
