Analytical Data
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基因名
OSM
- Application
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别名
OSM;Oncostatin-M
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13725
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表达区间
26-221aa
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氨基酸序列
AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRR
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分子量
22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSM (Oncostatin M) is a cytokine belonging to the interleukin-6 (IL-6) family, which plays a crucial role in various physiological processes, including inflammation, hematopoiesis, and cell differentiation. Research on OSM has gained significant attention due to its dual role in both promoting and inhibiting tumor progression, particularly in various cancers such as breast and prostate cancer. Its receptor complex, consisting of the OSM receptor and the glycoprotein 130 (gp130), activates several intracellular signaling pathways, including the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, which is implicated in the regulation of gene expression related to cell survival and growth. The understanding of OSM's structure and function, particularly through the study of its recombinant forms, provides insights into how OSM modulates immune responses and its potential therapeutic applications, including tumor immunotherapy and regenerative medicine. Given the complexity of OSM's role in both immune modulation and cancer biology, ongoing research aims to unravel its mechanism of action and explore its efficacy in clinical applications, thereby contributing to the development of novel treatment strategies targeting OSM in cancer and other diseases. This investigation into OSM's recombinant proteins not only enhances our understanding of its biological significance but also opens avenues for new therapeutic interventions that could leverage OSM's properties to manage various health conditions effectively.
