Analytical Data
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基因名
MMAA
- Application
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别名
MMAAMethylmalonic aciduria type A protein; mitochondrial; EC 3.6.-.-
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IVH4
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表达区间
66-418 aa
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氨基酸序列
CVQTT LKDHTEGLSD KEQRFVDKLY TGLIQGQRAC LAEAITLVES THSRKKELAQ VLLQKVLLYH REQEQSNKGK PLAFRVGLSG PPGAGKSTFI EYFGKMLTER GHKLSVLAVD PSSCTSGGSL LGDKTRMTEL SRDMNAYIRP SPTRGTLGGV TRTTNEAILL CEGAGYDIIL IETVGVGQSE FAVADMVDMF VLLLPPAGGD ELQGIKRGII EMADLVAVTK SDGDLIVPAR RIQAEYVSAL KLLRKRSQVW KPKVIRISAR SGEGISEMWD KMKDFQDLML ASGELTAKRR KQQKVWMWNL IQESVLEHFR THPTVREQIP LLEQKVLIGA LSPGLAADFL LKAFKSRD
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分子量
46.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MMAA (Methylmalonic Aciduria Associated Protein) is a key protein of interest in the study of metabolic disorders, particularly those related to methylmalonic aciduria, a rare inherited condition affecting the metabolism of certain amino acids and lipids. Individuals with this condition often experience a deficiency in the enzyme methylmalonyl-CoA mutase, which is crucial for the conversion of methylmalonyl-CoA into succinyl-CoA, leading to the accumulation of toxic levels of methylmalonic acid in the body. Research on MMAA focuses on understanding its structure, function, and the molecular mechanisms underlying its role in metabolic pathways. This protein is also implicated in cellular processes beyond metabolism, including cell signaling and stress responses. Advances in biophysical techniques, including X-ray crystallography and NMR spectroscopy, have facilitated a deeper understanding of MMAA's structure-function relationship. By unraveling the biochemical pathways and genetic mutations associated with MMAA, researchers aim to develop targeted therapies and management strategies to alleviate the symptoms associated with methylmalonic aciduria, ultimately improving the quality of life for affected individuals. Furthermore, insights gained from MMAA studies may have broader implications for understanding related metabolic disorders, making it a vital area of research in biomedical sciences.
