Analytical Data
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基因名
Syt12
- Application
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别名
Syt12；Synaptotagmin-12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IV01
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表达区间
1-421aa
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氨基酸序列
MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLATLRRPVSMWHAVRRN
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分子量
46.5kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Syt12, or Synaptotagmin 12, is a member of the synaptotagmin family of proteins, which are critical in synaptic transmission and vesicle trafficking due to their calcium-sensitive binding properties. Research into Syt12 has gained significance as it plays a role in the regulation of neurotransmitter release in the nervous system, particularly in the context of calcium-mediated signaling pathways. Syt12 is particularly interesting because it is thought to participate in intracellular trafficking and the exocytosis process in neurons, potentially contributing to synaptic plasticity and cognitive functions. Its unique isoform has made it a target of interest for understanding the molecular mechanisms behind neurodegenerative diseases and psychiatric disorders where synaptic dysfunction is evident. Recent studies involving Syt12 recombinant proteins have facilitated the exploration of its structural properties, binding affinity to phospholipids, and interaction with other synaptic proteins, thereby enhancing our understanding of its biological functions. By investigating the role of Syt12 in synaptic transmission and its potential involvement in pathological conditions, researchers aim to develop therapeutic strategies that address synaptic impairments, making Syt12 a promising candidate in the field of neuroscience.
