Analytical Data
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基因名
MON1B
- Application
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别名
5031407H10; 5033413H12Rik; HSRG1; HSV-1 stimulating-related protein; HSV-1 stimulation-related gene 1; HSV-1 stimulation-related gene 1 protein; HSV-I stimulating-related protein; Kiaa0872; MON1 homolog B (yeast); MON1 homolog B; Mon1b; MON1B_HUMAN; RGD1309977; SAND2; SRG1; Vacuolar fusion protein MON1 homolog B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L1V2
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表达区间
1-547 aa
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氨基酸序列
MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETG SKDKDQPPSP SPPPQSEALS STSRLWSPAA PENSPTCSPE SSSGGQGGDP SDEEWRSQRK HVFVLSEAGK PIYSRYGSVE ALSATMGVMT ALVSFVQSAG DAIRAIYAED HKLVFLQQGP LLLVAMSRTS QSAAQLRGEL LAVHAQIVST LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP GALLLGAVRC VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL LLLGTQREAF HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY SVQAVGAPGL RHFLYKPLDI PDHHRQLPQF TSPELEAPYS REEERQRLSD LYHRLHARLH STSRPLRLIY HVAEKETLLA WVTSKFELYT CLSPLVTKAG AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH NGLFTGL
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分子量
59.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MON1B is a crucial protein involved in intracellular membrane trafficking and endosomal function, playing a significant role in the regulation of protein sorting and recycling within cells. Its study has gained attention due to its implications in various cellular processes, including autophagy and mitophagy, which are vital for maintaining cellular homeostasis and responding to stress. Abnormalities in MON1B function have been linked to several diseases, such as neurodegenerative disorders and certain cancers. Recent research has focused on understanding the molecular mechanisms underlying MON1B's role in vesicular transport and its interactions with other proteins in the ENDOSOME-Mitochondria pathway. Investigations into MON1B have utilized techniques such as site-directed mutagenesis, protein crystallization, and advanced imaging methods to characterize its structure and function. Insights gained from these studies could provide invaluable information for therapeutic strategies targeting diseases associated with dysregulated intracellular transport mechanisms. Overall, the significance of MON1B in cellular dynamics underlines the importance of continued research in understanding its diverse functions and potential implications in health and disease.
