Analytical Data
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Gene name
CABP2
- Application
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Alternative Names
CABP2；Calcium-binding Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56545
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Expression Region
1-445aa
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AA Sequence
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPI LKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRV IVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNT WLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAK AFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNH HLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHES EPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIP ESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLP AAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
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Molecular Weight
75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CABP2 (Calcium Binding Protein 2) is a member of the calmodulin superfamily, which plays a pivotal role in calcium ion signaling within neurons. Its structure includes EF-hand motifs that enable it to bind calcium ions, thereby influencing various cellular processes such as synaptic transmission and neuronal excitability. Research on CABP2 has emerged due to its potential involvement in neurological disorders, including autism spectrum disorders and schizophrenia. Mutations in the CABP2 gene have been linked to altered calcium signaling pathways, which can disrupt normal neural functioning. Recent studies have focused on the recombinant expression of CABP2, enabling researchers to investigate its biochemical properties and functional roles in detail. By producing and purifying the recombinant CABP2 protein, scientists can perform various assays to elucidate its binding affinity for calcium and its interactions with other proteins involved in signaling pathways. Understanding CABP2's mechanistic role in calcium signaling may provide insights into its contribution to synaptic plasticity and neurological health, paving the way for potential therapeutic strategies targeting CABP2-related pathologies. These investigations underscore CABP2's significance in neuroscience and highlight the importance of protein studies in the context of gene mutations and their possible implications on brain function.
