Analytical Data
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Gene name
MRPL15
- Application
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Alternative Names
MRPL19; KIAA0104; MRPL15; 39S ribosomal protein L19; mitochondrial; L19mt; MRP-L19; 39S ribosomal protein L15; mitochondrial; L15mt; MRP-L15; Mitochondrial large ribosomal subunit protein bL19m
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49406
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Expression Region
1-292 aa
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AA Sequence
MAACIAAGHWAAMGLGRSFQAARTLLPPPASIACRVHAGPVRQQSTGPSEPGAFQPPPKPVIVDKHRPVEPERRFLSPEFIPRRGRTDPLKFQIERKDMLERRKVLHIPEFYVGSILRVTTADPYASGKISQFLGICIQRSGRGLGATFILRNVIEGQGVEICFELYNPRVQEIQVVKLEKRLDDSLLYLRDALPEYSTFDVNMKPVVQEPNQKVPVNELKVKMKPKPWSKRWERPNFNIKGIRFDLCLTEQQMKEAQKWNQPWLEFDMMREYDTSKIEAAIWKEIEASKRS
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Molecular Weight
60.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL15 (Mitochondrial Ribosomal Protein L15) is a vital component of the mitochondrial ribosome, playing a crucial role in protein synthesis within mitochondria. Due to its involvement in mitochondrial function, MRPL15 is essential for maintaining cellular energy levels and regulating metabolic processes. Dysregulation or mutations in MRPL15 have been implicated in various mitochondrial diseases, which can lead to severe health issues, including neuromuscular disorders and metabolic syndromes. Research on MRPL15 has gained significant attention in recent years as scientists aim to understand its structure, function, and the molecular mechanisms by which it contributes to mitochondrial integrity. Insights into MRPL15 may pave the way for therapeutic approaches targeting mitochondrial dysfunction, potentially offering new avenues for the treatment of related diseases. Additionally, MRPL15 serves as a model for studying the evolution of mitochondrial ribosomal proteins and their roles in the complex interplay of genetic expression and cellular metabolism. Overall, the study of MRPL15 is critical not only for elucidating mitochondrial biology but also for developing strategies to combat mitochondrial-related diseases.
