Analytical Data
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Gene name
PSTPIP1
- Application
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Alternative Names
PSTPIP1;CD2BP1;Proline-serine-threonine phosphatase-interacting Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43586
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Expression Region
1-416aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMMPQLQFKDAFWCRDFTAHTGYEVLLQ RLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTEINSLRASF DSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQ KSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKA RQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTIL RNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTE PPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAAS AASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDE LDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEKL
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSTPIP1, or Proline Serine Threonine Phosphatase Interacting Protein 1, is an important protein implicated in a range of cellular processes, including cytoskeletal organization and cellular signaling pathways. Originally identified in immune cells, PSTPIP1 plays a critical role in mediating interactions between the actin cytoskeleton and various signaling molecules. Mutations or dysregulation of PSTPIP1 have been linked to several pathological conditions, such as autoinflammatory diseases, most notably the systemic autoinflammatory disease called PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, and acne). Given its significant biological functions and implications in disease, researchers have turned to recombinant protein technology to study PSTPIP1 in detail. Producing PSTPIP1 as a recombinant protein enables scientists to investigate its structural properties, functional roles, and interactions with other proteins in vitro. This approach provides valuable insights into the mechanisms by which PSTPIP1 contributes to cellular dynamics and disease pathology. Understanding the structure-function relationship of PSTPIP1 can pave the way for potential therapeutic strategies targeting autoinflammatory diseases or other related conditions, highlighting the necessity of ongoing research in this field.
