Analytical Data
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基因名
OGC
- Application
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别名
OGC；SLC20A4；Mitochondrial 2-oxoglutarate/malate carrier Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02978
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表达区间
1-314aa
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氨基酸序列
MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQ LSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLG IYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTAD GRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA SYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNM RMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL EQMNKAYKRLFLSG
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of OGC (ornithine transcarbamylase) recombinant proteins is pivotal in understanding metabolic disorders, particularly those associated with urea cycle deficiencies. OGC plays a crucial role in the conversion of ornithine and carbamoyl phosphate into citrulline, a key step in the urea cycle that detoxifies ammonia in the liver. Mutations in the OTC gene, which encodes OGC, lead to hyperammonemia and can result in severe neurological damage or even mortality if left untreated. Recombinant OGC proteins are vital for developing novel therapeutic strategies, including enzyme replacement therapies and gene therapy approaches, aimed at correcting the underlying genetic deficiencies. Furthermore, producing OGC in a recombinant form allows for detailed structural and functional studies, which facilitate the design of small molecules or substrates that can enhance its activity or stability. Thus, research involving OGC recombinant proteins not only advances our understanding of urea cycle disorders but also opens avenues for innovative treatments, ultimately improving patient outcomes in conditions stemming from urea cycle dysfunction.
