Analytical Data
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基因名
NKD2
- Application
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别名
hNkd2; Naked 2; Naked-2; nkd2; NKD2_HUMAN; Protein naked cuticle homolog 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q969F2
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表达区间
2-451 aa
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氨基酸序列
GKLQSKHAA AARKRRESPE GDSFVASAYA SGRKGAEEAE RRARDKQELP NGDPKEGPFR EDQCPLQVAL PAEKAEGREH PGQLLSADDG ERAANREGPR GPGGQRLNID ALQCDVSVEE DDRQEWTFTL YDFDNCGKVT REDMSSLMHT IYEVVDASVN HSSGSSKTLR VKLTVSPEPS SKRKEGPPAG QDREPTRCRM EGELAEEPRV ADRRLSAHVR RPSTDPQPCS ERGPYCVDEN TERRNHYLDL AGIENYTSRF GPGSPPVQAK QEPQGRASHL QARSRSQEPD THAVHHRRSQ VLVEHVVPAS EPAARALDTQ PRPKGPEKQF LKSPKGSGKP PGVPASSKSG KAFSYYLPAV LPPQAPQDGH HLPQPPPPPY GHKRYRQKGR EGHSPLKAPH AQPATVEHEV VRDLPPTPAG EGYAVPVIQR HEHHHHHEHH HHHHHHHFHP S
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分子量
50.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NKD2, or Naked Cuticle 2, is a member of the Naked Cuticle family, which plays a crucial role in regulating planar cell polarity (PCP) and modulating various signaling pathways in developmental biology. The research surrounding NKD2 has gained momentum due to its involvement in key developmental processes and its potential implications in cancer biology, particularly in tumorigenesis and metastasis. Studies have shown that NKD2 functions as an antagonist of Wnt signaling, which is vital for numerous cellular processes, including proliferation, differentiation, and migration. Given the importance of Wnt signaling in various physiological and pathological conditions, the recombination of NKD2 protein allows for the detailed examination of its interactions and regulatory mechanisms. Researchers are particularly interested in characterizing the structure and function of NKD2 to understand its role in cell fate decisions and to explore its potential as a therapeutic target. The production of recombinant NKD2 protein facilitates various biochemical assays, including protein-protein interaction studies, structural analysis, and functional assays, which are critical for elucidating its biological roles and pathways. Advances in NKD2 research could contribute to a better understanding of developmental disorders and malignancies associated with aberrant Wnt signaling, paving the way for novel therapeutic strategies. Overall, the study of NKD2 reconstituted protein not only enhances our understanding of fundamental cellular processes but also offers insights into potential clinical applications in regenerative medicine and oncology.
