Analytical Data
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基因名
ELMO1
- Application
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别名
ELMO1；KIAA0281；Engulfment and cell motility Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92556
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表达区间
1-727aa
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氨基酸序列
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFA LQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAK LEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPC FGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQR SLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINAL FLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVL TFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKS MYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVL ENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDR SFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLD QFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQ QRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVP HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNC QLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLD LENIQIPDAPPPIPKEPSNYDFVYDCN
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分子量
110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELMO1 (Engulfment and Cell Motility 1) is a crucial protein implicated in various cellular processes, including apoptosis, cell migration, and immune response. Research into ELMO1 has gained traction due to its involvement in critical pathways associated with cancer progression and inflammation. ELMO1 is part of the ELMO-Dock-Rac signaling complex, which plays a vital role in regulating the actin cytoskeleton, thereby influencing cell shape and motility. Abnormal expression or mutation of ELMO1 has been linked to several types of cancer, including breast, lung, and colorectal cancer, making it a potential biomarker for tumor progression and a target for therapeutic intervention. Additionally, ELMO1’s role in phagocytosis and immune response highlights its importance in understanding autoimmune diseases and infectious diseases. The recombinant expression of ELMO1 protein allows for detailed biochemical characterization and provides insights into its functional mechanisms. Continued research on ELMO1 not only enhances our understanding of cellular dynamics but also paves the way for novel therapeutic strategies in treating cancer and inflammatory diseases.
