Analytical Data
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Gene name
gABRg2
- Application
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Alternative Names
gABRg2；Gamma-aminobutyric acid receptor subunit gamma-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P18507
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Expression Region
1-475aa
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AA Sequence
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
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Molecular Weight
55.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on the recombinant GABRg2 protein is driven by its critical role in the function of gamma-aminobutyric acid (GABA) receptors, which are the primary inhibitory neurotransmitter receptors in the central nervous system. The GABRg2 subunit is essential for the formation of GABA_A receptors, influencing various physiological processes including anxiety, sedation, and motor control. Abnormalities in GABAergic signaling have been implicated in a variety of neurological disorders such as epilepsy, anxiety disorders, and schizophrenia, making the study of these receptors vital for understanding their mechanisms and developing therapeutics. By generating recombinant GABRg2 proteins, researchers can investigate the structural and functional characteristics of GABA_A receptors in a controlled environment, allowing for more detailed studies of ligand binding, receptor configurations, and pharmacological interactions. This research not only enhances our fundamental understanding of neurotransmission but also opens doors for drug discovery aimed at modulating GABAergic activity, providing potential avenues for the treatment of related psychiatric and neurological conditions. Moreover, advancements in recombinant protein technology facilitate the production of more stable and functional receptor models, fostering the exploration of new therapeutic agents and approaches to restore the balance of inhibitory signaling in the brain.
