Analytical Data
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基因名
ACCN2
- Application
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别名
ACCN2; ACCN2_HUMAN; Acid sensing ion channel 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal.
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78348
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表达区间
1-528aa
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氨基酸序列
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
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分子量
86.3 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ACCN2 (acid-sensing ion channel 2) protein is a member of the amiloride-sensitive sodium channel family, playing a crucial role in the detection of changes in extracellular acidity. It is predominantly expressed in the central nervous system and plays a significant role in various physiological processes, including pain sensation, neuroprotection, and modulation of synaptic activity. Research into ACCN2 has gained momentum due to its involvement in pathological conditions, such as chronic pain and neurodegenerative diseases, where altered acid sensing may contribute to neuronal excitability and inflammation. The recombinant expression of ACCN2 has become a pivotal focus for understanding its structure-function relationship and for evaluating its potential as a therapeutic target. Through the production of recombinant ACCN2 proteins, researchers can investigate biophysical properties, ion selectivity, and pharmacological interactions, facilitating the development of drugs to modulate its activity. Furthermore, structural studies of ACCN2 provide insights into the molecular mechanisms underlying its function and regulation. As research progresses, the exploration of ACCN2's role in disease contexts may yield novel avenues for intervention in acid-related pathologies and enhance our understanding of ion channel biology.
