Analytical Data
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Gene name
ACCN5
- Application
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Alternative Names
amiloride sensitive cation channel 5. intestinal、Amiloride sensitive sodium channel
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal.
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NY37
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Expression Region
1-505aa
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AA Sequence
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
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Molecular Weight
82.5 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACCN5, also known as the acid-sensing ion channel 5, is a member of the transient receptor potential (TRP) channel family and is primarily involved in sensing environmental changes, particularly in response to acidic pH. This channel has gained attention in recent years due to its potential role in various physiological and pathophysiological processes, including pain sensation, neurotransmission, and cellular signaling. Understanding ACCN5's structure and function is crucial for elucidating its mechanisms in these processes, which may contribute to the development of new therapeutic strategies for managing pain and other disorders. The study of recombinant ACCN5 protein is essential for characterizing its biophysical properties, ion permeability, and interaction with other cellular components. By producing and analyzing ACCN5 in a controlled laboratory setting, researchers can decipher its functional roles and potentially identify small molecules or drugs that selectively modulate its activity. Additionally, recombinant ACCN5 can be used to investigate its involvement in diseases such as inflammation and neurodegeneration, paving the way for innovative treatments that target this channel. Therefore, research on ACCN5 recombinant protein is a promising direction in both basic science and applied medical research, with implications for understanding pain mechanisms and developing new interventions for related conditions.
