Analytical Data
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基因名
SURF1
- Application
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别名
SURF1；SURF-1；Surfeit locus Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15526
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表达区间
1-300aa
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氨基酸序列
MAAVAALQLGLRAAGLGRAPASAAWRSVLRVSPRPGVAWRPSRCGSSAAEASATKAEDDSFLQWVLLLIPVTAFGLGTWQVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYIVTWYGLSAATSYLWFKKFLRGTPGV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SURF1 (Surfeit 1) is a gene that encodes a protein involved in the assembly and function of mitochondrial respiratory chain complexes, particularly Complex IV, which is crucial for cellular energy production through oxidative phosphorylation. Research has shown that mutations in the SURF1 gene are associated with a rare autosomal recessive form of Leigh syndrome, a severe neurological disorder characterized by progressive loss of mental and movement abilities, typically arising in infancy or early childhood. The study of SURF1 recombinant proteins has gained importance in understanding mitochondrial dysfunction and its links to neurodegenerative diseases. By producing and analyzing SURF1 proteins in vitro, researchers can investigate their structural properties, folding dynamics, and interactions with other mitochondrial proteins. This research not only provides insights into the pathophysiological mechanisms underlying Leigh syndrome but also contributes to the broader understanding of mitochondrial biology. Furthermore, studying SURF1 may help identify potential therapeutic targets or strategies to mitigate the effects of mitochondrial defects. As the field of mitochondrial medicine expands, the exploration of SURF1 and its recombinant proteins remains a critical area for developing innovative treatments for mitochondrial disorders and improving patient outcomes.
