Analytical Data
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Gene name
TACO1
- Application
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Alternative Names
TACO1；CCDC44；Translational activator of cytochrome c oxidase 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BSH4
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Expression Region
61-297aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSNKWSKVR HIKGPKDVER SRIFSKLCLN IRLAVKEGGP NPEHNSNLAN ILEVCRSKHM PKSTIETALK MEKSKDTYLL YEGRGPGGSS LLIEALSNSS HKCQADIRHI LNKNGGVMAV GARHSFDKKG VIVVEVEDRE KKAVNLERAL EMAIEAGAED VKETEDEEER NVFKFICDAS SLHQVRKKLD SLGLCSVSCA LEFIPNSKVQ LAEPDLEQAA HLIQALSNHE DVIHVYDNIE
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Molecular Weight
29 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TACO1 (Transcriptionally Active Chromatin-Associated 1) is a crucial protein involved in mitochondrial function and cellular metabolism. Its primary role revolves around the regulation of mitochondrial ribosomal RNA and the synthesis of mitochondrial proteins, which are essential for proper energy production and overall cellular health. Recent studies have highlighted the significance of TACO1 in various cellular processes, including oxidative stress response and apoptosis, suggesting its potential involvement in several pathological conditions, such as neurodegenerative diseases and cancer. Research on recombinant TACO1 has gained momentum due to its promise as a target for therapeutic interventions aimed at enhancing mitochondrial function or correcting mitochondrial dysfunction linked to disease. The generation of recombinant TACO1 protein allows for detailed characterization of its biochemical properties, interaction partners, and functional mechanisms in vitro, providing insights into its role within the mitochondrial context. Furthermore, understanding the structure-function relationship of TACO1 through protein engineering and modification could lead to the development of novel strategies for treating diseases associated with mitochondrial impairment. As such, the study of TACO1 not only enhances our fundamental understanding of mitochondrial biology but also paves the way for potential translational applications in the field of medicine, where optimizing mitochondrial health could prove invaluable for a wide range of diseases.
