Analytical Data
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Gene name
P2RY8
- Application
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Alternative Names
P2RY8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VZ1
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Expression Region
1-359 aa
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AA Sequence
MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF
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Molecular Weight
40.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
P2RY8, a member of the purinergic receptor family, encodes a G protein-coupled receptor that is primarily expressed in immune cells, particularly B lymphocytes. Its involvement in cellular signaling pathways, particularly in response to extracellular ATP and other purines, has garnered attention due to its potential role in immune response modulation. Research has indicated that P2RY8 is implicated in various autoimmune diseases, lymphoproliferative disorders, and certain types of cancer. Importantly, the receptor's gene is located on the X chromosome, making it subject to unique regulatory mechanisms and mutations that may contribute to sex-specific predispositions in disease. The development of recombinant P2RY8 protein has become a focal point of study to elucidate its functional properties, signaling mechanisms, and interactions with other cellular components. Understanding the structure and activity of P2RY8 is crucial for exploring its therapeutic potential, particularly in harnessing its role in immune system regulation and identifying novel targets for treatment strategies in related diseases. Research efforts are ongoing to characterize this protein further, with hopes of unraveling its complexities and contributing to the broader understanding of purinergic signaling in health and disease.
