Analytical Data
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基因名
ARHGAP24
- Application
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别名
ARHGAP24; FILGAP; Rho GTPase-activating Protein 24; Filamin-A-associated RhoGAP
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N264
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表达区间
1-748aa
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氨基酸序列
MEENNDSTEN PQQGQGRQNA IKCGWLRKQG GFVKTWHTRW FVLKGDQLYY FKDEDETKPL GTIFLPGNKV SEHPCNEENP GKFLFEVVPG GDRDRMTANH ESYLLMASTQ NDMEDWVKSI RRVIWGPFGG GIFGQKLEDT VRYEKRYGNR LAPMLVEQCV DFIRQRGLKE EGLFRLPGQA NLVKELQDAF DCGEKPSFDS NTDVHTVASL LKLYLRELPE PVIPYAKYED FLSCAKLLSK EEEAGVKELA KQVKSLPVVN YNLLKYICRF LDEVQSYSGV NKMSVQNLAT VFGPNILRPK VEDPLTIMEG TVVVQQLMSV MISKHDCLFP KDAELQSKPQ DGVSNNNEIQ KKATMGQLQN KENNNTKDSP SRQCSWDKSE SPQRSSMNNG SPTALSGSKT NSPKNSVHKL DVSRSPPLMV KKNPAFNKGS GIVTNGSFSS SNAEGLEKTQ TTPNGSLQAR RSSSLKVSGT KMGTHSVQNG TVRMGILNSD TLGNPTNVRN MSWLPNGYVT LRDNKQKEQA GELGQHNRLS TYDNVHQQFS MMNLDDKQSI DSATWSTSSC EISLPENSNS CRSSTTTCPE QDFFGGNFED PVLDGPPQDD LSHPRDYESK SDHRSVGGRS SRATSSSDNS ETFVGNSSSN HSALHSLVSS LKQEMTKQKI EYESRIKSLE QRNLTLETEM MSLHDELDQE RKKFTMIEIK MRNAERAKED AEKRNDMLQK EMEQFFSTFG ELTVEPRRTE RGNTIWIQ
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分子量
84.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGAP24, a member of the Rho GTPase-activating protein family, plays a critical role in regulating the Rho family of GTPases, particularly RhoA and Rac1, which are key players in various cellular processes including cytoskeletal dynamics, cell migration, and adhesion. As a result, ARHGAP24 is implicated in fundamental biological processes such as the regulation of cell morphology, cytokinesis, and the immune response. Recent studies have highlighted the importance of ARHGAP24 in cancer progression, particularly its potential role in tumorigenesis and metastasis, as it can modulate signaling pathways that influence cell proliferation and motility. Given its regulatory effects on Rho GTPases, ARHGAP24 has emerged as a potential target for therapeutic interventions aimed at controlling undesirable cell migration and invasion. The recombinant expression of ARHGAP24 in various model systems facilitates in-depth studies regarding its structural characteristics and functional mechanisms. By generating and purifying the recombinant protein, researchers can perform biochemical assays, assess protein interactions, and elucidate the functional implications of ARHGAP24 in cellular contexts. Understanding the modulation of Rho GTPases by ARHGAP24 could pave the way for novel strategies in cancer treatment and for the development of drugs that specifically target this pathway, thereby enhancing our ability to combat cancer metastasis and related disorders. Overall, the recombinant protein study of ARHGAP24 not only provides insights into its biological significance but also holds promise for advancing therapeutic approaches in oncology.
