Analytical Data
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基因名
TPSAB1
- Application
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别名
TPSAB1；TPS1；Tryptase alpha/beta-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15661
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表达区间
31-275aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMIVGGQEAPRSKWPWQVSLRVHGPYW MHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVS RIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPC WVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIV RDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPG IYTRVTYYLDWIHHYVPKKP
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPSAB1, or Tryptase Beta 1, is a serine protease predominantly expressed in mast cells and plays a crucial role in various physiological and pathological processes, including inflammation, allergic responses, and tissue remodeling. Research into TPSAB1 has gained significant interest due to its involvement in the pathogenesis of various diseases, such as asthma, chronic rhinosinusitis, and certain autoimmune conditions. Abnormal expression or activity of TPSAB1 has been linked to increased mast cell degranulation, leading to the release of pro-inflammatory cytokines and other mediators. This has prompted investigations into the potential of TPSAB1 as a therapeutic target for controlling allergic reactions and other mast cell-related disorders. Additionally, the development of recombinant forms of TPSAB1 allows for in-depth study of its biological functions and interactions, facilitating the discovery of inhibitors that could mitigate its detrimental effects in disease contexts. Understanding the molecular mechanisms governing TPSAB1 activity may pave the way for novel treatment approaches aimed at modulating mast cell function and improving patient outcomes in allergic and inflammatory diseases.
