Analytical Data
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基因名
TREM2
- Application
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别名
TREM2；Triggering receptor expressed on myeloid cells 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZC2
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表达区间
19-174aa
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氨基酸序列
HNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHN LWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEA DTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSISRSLLEGEI PFPPTS
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is an immune receptor predominantly expressed on microglia, the resident immune cells of the central nervous system. Recent research has highlighted its critical role in neuroinflammation and neurodegenerative diseases, particularly Alzheimer's disease. Mutations in the TREM2 gene have been linked to an increased risk of developing late-onset Alzheimer's, suggesting that TREM2 signaling pathways are essential for maintaining brain homeostasis and modulating inflammatory responses. Given its significance, the production of recombinant TREM2 protein has gained prominence in scientific research, allowing for detailed studies on its structure, function, and interactions with various ligands. Understanding the mechanisms by which TREM2 operates can provide insights into its protective roles in the brain and promote the exploration of TREM2 as a potential therapeutic target. Thus, the study of recombinant TREM2 protein not only elucidates its biological functions but also aims to advance our knowledge of its implications in neurodegenerative diseases, paving the way for novel treatment strategies.
