Analytical Data
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基因名
ZWILCH
- Application
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别名
ZWILCH；Protein zwilch homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H900
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表达区间
1-591aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMWERLNCAAEDFYSRLLQKFNEEKKGI RKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHI EELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKIN LPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKN YSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIAL DISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLAD GLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKH DTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSL QRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDK LKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSC MPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEK PQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERI FFTNMVTCSQVHFK
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分子量
70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZWILCH is a protein that plays a crucial role in the regulation of cell division, particularly in the proper functioning of the spindle assembly checkpoint during mitosis. Research on ZWILCH has gained prominence due to its involvement in ensuring accurate chromosome segregation, which is vital for maintaining genomic stability. Aberrations in this process can lead to aneuploidy and are often implicated in various cancers. Studies have highlighted ZWILCH's interactions with other key proteins involved in the mitotic apparatus, shedding light on its function and importance in cellular processes. The understanding of ZWILCH's role has implications not only for basic cell biology but also for potential therapeutic approaches in cancer treatment, where targeting the mechanisms of cell division could enhance the efficacy of existing therapies. As such, investigations into the structure, function, and regulation of ZWILCH continue to be an active area of research, aiming to unravel the complexities of mitotic regulation and its implications for disease.
