Recombinant Human ARID1A Protein，His

ARID1A (AT-rich interactive domain-containing protein 1A) is a crucial component of the SWI/SNF chromatin remodeling complex, playing a significant role in regulating gene expression and maintaining genomic integrity. Its dysfunction has been implicated in various human cancers, particularly ovarian clear cell carcinoma and endometrial carcinoma, where ARID1A mutations or loss of expression are frequently observed. The protein facilitates the remodeling of chromatin, influencing DNA accessibility and transcriptional activity. Research has highlighted that ARID1A mutations not only disrupt its role in chromatin dynamics but also lead to impaired cellular responses to DNA damage and stress. Consequently, understanding the molecular mechanisms underlying ARID1A functionality and its dysregulation in cancer is critical for the development of targeted therapies. Current studies have focused on elucidating the interaction networks involving ARID1A, its post-translational modifications, and the downstream effects on cell cycle regulation and apoptosis. As a result, ARID1A has garnered attention as a potential biomarker for cancer diagnosis and prognosis, as well as a promising target for innovative therapeutic strategies aimed at restoring its normal functions or compensating for its loss in tumor contexts.