Analytical Data
-
Gene name
Asgr1
- Application
-
Alternative Names
Asgr1；CLEC4H1；AsialoglycoProtein receptor 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P07306
-
Expression Region
68-291aa
-
AA Sequence
EELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
-
Molecular Weight
29.7kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Asgr1, or asialoglycoprotein receptor 1, is a key receptor involved in the clearance of glycoproteins that lack sialic acid residues from circulation, primarily found in the liver. Its significant role in mediating endocytosis and facilitating cellular uptake of various ligands makes it a focal point in research related to drug delivery, gene therapy, and the treatment of liver diseases. The study of recombinant Asgr1 proteins has gained traction due to their potential applications in targeted therapies; for instance, engineers can utilize these proteins to enhance the specificity of therapeutic agents for liver-targeted interventions. Moreover, Asgr1 is implicated in various physiological processes, including immune response and metabolism, which prompts further investigation into its structure and function. Understanding the structure-function relationships of Asgr1 through recombinant technology offers insights into its mechanism and could lead to the development of novel therapeutic strategies aimed at optimizing liver-targeted drug delivery systems. The ability to produce Asgr1 in recombinant form also allows for detailed biochemical and biophysical analyses, which are essential for elucidating its interactions with ligands and other cellular components. Overall, the research on Asgr1 recombinant proteins not only contributes to fundamental biological knowledge but also holds promise for advancing clinical applications in liver-targeted therapies.
