Analytical Data
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Gene name
Ccn3
- Application
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Alternative Names
Ccn3；IGFBP9；CCN family member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48745
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Expression Region
28-357aa
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AA Sequence
M+QVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
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Molecular Weight
36.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCN3, also known as nephroblastoma overexpressed gene (NOV), is a member of the CCN (Cyr61/CTGF/NOV) family of secreted proteins that play crucial roles in various biological processes, including cell proliferation, differentiation, and tissue repair. The study of CCN3 has garnered attention due to its significant involvement in pathological conditions, particularly in kidney and bone diseases, as well as its potential role in cancer progression. Research indicates that CCN3 can regulate multiple signaling pathways, influencing processes such as extracellular matrix production and cell-matrix interactions. Moreover, its expression is often dysregulated in tumors, suggesting a potential tumor suppressive function in certain contexts. The functions of CCN3 are mediated through its interactions with integrins and growth factor receptors, pointing to its importance in cellular communication and microenvironmental modulation. As a result, recombinant CCN3 proteins have been investigated for their therapeutic potential, providing insights into their role in regenerative medicine and the development of biomaterials. Additionally, the characterization of CCN3 at the molecular level is essential for understanding its various biological implications, making it a focal point for ongoing research aimed at harnessing its properties for clinical applications. The growing interest in CCN3 underscores the need for comprehensive studies to elucidate its exact mechanisms and broaden its potential uses in medical science.
