Analytical Data
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Gene name
CALM1
- Application
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Alternative Names
CALM1；CALM；Calmodulin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0DP23
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Expression Region
1-149aa
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AA Sequence
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CALM1 (Calmodulin 1) is an essential calcium-binding protein that plays a crucial role in various cellular processes, including muscle contraction, neurotransmitter release, and gene expression regulation. The CALM1 gene encodes a protein that interacts with numerous target proteins in response to changes in intracellular calcium levels, acting as a mediator for calcium signaling pathways. Dysregulation of CALM1 has been implicated in various diseases, including cardiovascular disorders, neurological conditions, and cancer. Recent advances in recombinant protein technology have enabled researchers to produce CALM1 at significant scales, facilitating extensive studies to elucidate its structure, function, and interactions with other proteins. Understanding the detailed mechanisms by which CALM1 operates and its role in pathology could provide valuable insights for developing novel therapeutic approaches aimed at modulating calcium signaling pathways. Moreover, recombinant CALM1 can serve as a tool for biochemical assays and structural studies, contributing to a deeper understanding of calcium-dependent signaling processes in health and disease. This research not only enhances our knowledge of CALM1’s biological significance but also opens avenues for innovative treatments targeting calcium dysregulation in various pathological contexts.
