Analytical Data
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Gene name
Calcitonin/CALCA
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简介
The Calcitonin/CALCA protein induces vasodilation in different blood vessels, including the coronary, cerebral, and systemic vasculature. It is highly concentrated in the central nervous system, suggesting a role as a neurotransmitter or neuromodulator. Moreover, it increases platelet cAMP levels, possibly affecting platelet function. Calcitonin/CALCA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Calcitonin/CALCA protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Biological Activity
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 4.133 µg/mL. Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 4.133 μg/mL, corresponding to a specific activity is 241.9 units/mg.
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Alternative Names
Calcitonin; CCP; PDN-21; CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; PCT; Procalcitonin; Calcitonin 1; Katacalcin
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
Q99JA0
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Expression Region
V26-F119
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Protein Length
Full Length of Mature Peptide (with propeptide)
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Molecular Weight
42-48 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Calcitonin, a peptide hormone produced by the parafollicular cells of the thyroid gland, plays a crucial role in calcium homeostasis, primarily by inhibiting osteoclast activity and reducing bone resorption. The discovery of the CALCA gene, which encodes calcitonin and its related peptides, has spurred interest in understanding its biological functions and therapeutic potential. Research has demonstrated that calcitonin can be beneficial in treating osteoporosis and related bone disorders by decreasing the risk of fractures. Furthermore, its analgesic properties have garnered attention for potential applications in pain management, particularly in conditions such as arthritis and certain cancer-related pain. The recombinant production of calcitonin and CALCA-derived proteins allows for detailed study and potential clinical applications. These recombinant proteins offer advantages in terms of purity, consistency, and scalability, facilitating research into their mechanisms of action and efficacy. As scientists explore the multifaceted roles of calcitonin, including its interactions with other signaling pathways and cellular processes, the development of novel therapeutic strategies is on the horizon, harnessing the potential benefits of this hormone in regenerative medicine and orthopedic treatments.
